Adamax Research Peptide

Adamax is a synthetic research peptide described as a Semax analogue with an adamantane group attached. Semax itself is a seven-residue peptide based on a fragment of the hormone ACTH. Adamax is used in exploratory laboratory work on how chemical modification changes a Semax-type peptide, and it has not yet been characterised in peer-reviewed studies.

Adamax is built on the Semax sequence, Met-Glu-His-Phe-Pro-Gly-Pro, with an acetyl group on the front and an adamantane group added. Semax has been studied for decades in rodent and cell models, while Adamax has no published studies. Researchers comparing the two therefore treat Semax as the documented reference compound and Adamax as the modified test compound.

Adamantane is a rigid, cage-shaped molecule of ten carbon atoms, the same shape as a tiny piece of diamond lattice. Chemists add it to drug-like molecules to make them more fat-soluble and bulkier, which can change how they cross membranes and how quickly enzymes reach them. Whether it does either for Adamax has not been tested in published work.

Adamax is a supplier name rather than a compound defined in a paper or patent, so there is no single agreed reference structure. Most suppliers describe an acetylated Semax chain with adamantane at the end, but one catalogue listing gives an acetylated nine-residue sequence with no adamantane. That is why batch mass spectrometry is the most useful document for this compound.

Not under that name. A PubMed search in October 2026 returned no papers on the Adamax peptide; the results that do appear refer to a computer algorithm of the same name. There is also no CAS number or PubChem compound record. All published biological data in this area relate to Semax and other compounds, not to Adamax.

It is the scientific shorthand for Semax. “ACTH(4-7)” means residues 4 to 7 of the hormone ACTH, Met-Glu-His-Phe, and “PGP” is the Pro-Gly-Pro tail added in place of the hormone’s own residues 8 to 10. Adamax keeps this same seven-residue core, so papers indexed under ACTH(4-7)PGP form the main background reading for it.

Only by approach. P21, also written P021, is a separate research peptide that incorporates adamantane and was reported in 2010 to improve learning tasks and new neuron formation in mice. Suppliers sometimes mention it because it shows adamantane being used in a short peptide, but it has a different sequence and is not derived from Semax.

BDNF is a growth factor that supports nerve cells and the connections between them, and trkB is its receptor. In a 2006 rat study, a single application of Semax raised hippocampal BDNF protein 1.4-fold, trkB activation 1.6-fold and one form of BDNF messenger RNA three-fold. These are parent-compound findings and have not been measured for Adamax.

When Semax was incubated with rat brain cell cultures and membranes, enzymes mainly clipped off the first two residues or the last two, leaving five-residue fragments. Knowing where a peptide is cut tells chemists where a modification such as acetylation or a bulky end group might slow breakdown, which is the reasoning usually given for analogues like Adamax.

Researchers blocked the middle cerebral artery in rats and measured activity across the whole genome in the cortex at 3 and 24 hours. In animals given Semax, more than half of the altered genes were linked to the immune response, and others to blood vessel formation. Similar work has not been reported for Adamax.

HPLC shows how pure a sample is, but not which molecule it is. With Adamax, the structures described by suppliers differ, and plain Semax or N-acetyl Semax could look similar on HPLC. Mass spectrometry measures the actual molecular mass, so researchers can confirm that the adamantane-modified material in the vial matches the batch’s Certificate of Analysis.

Adamax is not a controlled drug under the Misuse of Drugs Act 1971, and it is not a licensed medicine in the UK. It is sold in the UK as a research compound for laboratory use only, which is how Crown Peptides supplies it. This is general information, not legal advice.

Adamax is coming soon to Crown Peptides in 10mg vials, available singly or in packs of 3, 5 or 10 with a saving on every vial. Orders ship from the UK, and every batch is independently tested, with its Certificate of Analysis, including the mass spectrometry result, published on this page once stock arrives.

Supplier-reported molecular weights for Adamax are close to 1,000 daltons, so 10mg is roughly 10 micromoles; the exact figure depends on the mass confirmed on your batch’s Certificate of Analysis. Semax binding sites were measured at nanomolar concentrations, so one vial covers a good deal of in vitro work, and the 5 and 10-vial packs keep a longer project on one batch.

Keep the unreconstituted powder at -20°C ± 5°C, dry and away from light. The sequence begins with methionine, an amino acid that oxidises readily on exposure to air and moisture, so vials are best kept sealed until use. Prepared solutions should follow storage conditions validated for your study design, and each batch’s Certificate of Analysis documents the material as dispatched.