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TB-500 peptide UK 5mg 10mg vial - Crown Peptides

Research Peptides

TB-500 (Thymosin Beta-4) Research Peptide

A high-purity research peptide studied in tissue repair and recovery research. Available in 5mg and 10mg, with every batch independently tested and dispatched from the UK.

£24.99or from £18.74 per vial in packs of 10
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Product Overview

A high-purity research peptide studied in tissue repair and recovery research. Available in 5mg and 10mg, with every batch independently tested and dispatched from the UK.

Full Product Specification
Overview

Product Overview

TB-500 peptide UK is Crown Peptides' Thymosin Beta-4-related research peptide, supplied in 5mg and 10mg vials for laboratory research into actin-sequestering biology, cell migration and angiogenesis.

5mg & 10mgAvailable strengthsHPLC testedChromatographic purityMS verifiedIdentity confirmedBatch CoADocumentation supplied

Supplied for laboratory research purposes only — not for human consumption or for medical, veterinary or diagnostic use.

Key features

Key Features

  • Studied in research involving actin-sequestering biology
  • Studied in research involving cell migration
  • Studied in research involving angiogenesis research
  • Studied in research involving wound-healing and tissue-response models
  • Batch-specific quality documentation available
Background

About TB-500 Peptide UK

Almost every cell in the body is already carrying thymosin beta-4. It is one of the most abundant peptides inside mammalian cells, and its everyday job is holding actin, the protein that forms the cell's internal scaffolding, in reserve until the cell needs to move, divide or change shape. That simple role has made it one of the most closely studied peptides in tissue-repair research.

Thymosin beta-4 is a naturally occurring 43-amino-acid peptide, first sequenced by Allan Goldstein's group from calf thymus extracts in the early 1980s, and best known for binding monomeric (G-) actin. TB-500 is the name used for thymosin beta-4 material supplied for laboratory research, and the Crown Peptides specification matches the full 43-residue sequence, with a molecular weight of 4963.49 g/mol.

Much of the research interest centres on a short stretch of that sequence, residues 17 to 23 (LKKTETQ), which forms the actin-binding site. Studies have linked this region to the peptide's effects on cell migration and new blood-vessel formation, which is why TB-500 comes up so often in angiogenesis and wound-model research.

Research

TB-500 Research

Thymosin Beta-4-related research includes actin sequestration, cell migration, angiogenesis, wound-healing models and tissue-response biology, with the actin-binding domain itself identified as the region driving angiogenic activity in experimental models (Learn more). Because actin dynamics influence cell movement and structural organisation, the peptide has been studied in epithelial, endothelial and connective-tissue models, alongside related tissue-repair peptides such as [BPC-157] and [KLOW]. Researchers should distinguish the exact TB-500 material supplied from full-length endogenous thymosin beta-4 where the product specification differs.

Wound-model research. One of the most cited studies, published in the Journal of Investigative Dermatology in 1999, used a rat full-thickness wound model. Thymosin beta-4 increased re-epithelialisation by 42% over controls at day 4 and by up to 61% at day 7, with more collagen deposition and new blood-vessel growth in the treated wounds (Learn more).

Cardiac research. In 2004, a study in Nature showed that thymosin beta-4 forms a complex with PINCH and integrin-linked kinase, activating the survival kinase Akt. In a mouse coronary-ligation model it enhanced early heart-muscle cell survival and improved cardiac function, opening up a whole field of research into the peptide and cardiac repair (Learn more).

Eye and cornea research. Thymosin beta-4 has also been studied extensively in corneal injury models, where it has been reported to speed up wound closure and reduce inflammatory markers. That work led to ophthalmic formulations of the peptide being taken into clinical development.

TB-500 and BPC-157. TB-500 is regularly researched alongside BPC-157, and the two work in different ways. TB-500's activity centres on actin and cell migration, while BPC-157 is a 15-amino-acid peptide derived from a gastric protein, studied mainly for its effects on growth-factor and nitric-oxide signalling. Because the two routes complement each other, many researchers study them together, which is where the pre-mixed Wolverine Stack comes in. Our BPC-157 vs TB-500 guide compares them in more depth.

  • Actin-sequestering biology
  • Cell migration
  • Angiogenesis research
  • Wound-healing and tissue-response models
Specifications

Specifications

Product
TB-500 / Thymosin β4
Classification
Thymosin Beta-4-related research peptide
Available strengths
5mg and 10mg
CAS number
77591-33-4
Molecular weight
4963.49 g/mol
Molecular formula
C212H350N56O78S
Purity and assay
99% (HPLC), batch-specific — refer to Certificate of Analysis
Verification
HPLC and Mass Spectrometry where analytically appropriate

Compound-level reference data. Batch-specific results appear on the Certificate of Analysis.

Work out concentration with the peptide calculator
Testing

Purity and Testing

Crown Peptides TB-500 / Thymosin β4 is supplied for controlled laboratory research with batch-specific analytical documentation. High-Performance Liquid Chromatography (HPLC) can assess chromatographic purity, while Mass Spectrometry provides molecular information used to support identity verification. The batch-specific Certificate of Analysis is the definitive source for the exact purity result, identity data and analytical specification of the material supplied.

Storage

Storage Conditions

  • Store unreconstituted material at -20°C ± 5°C in a cool, dry environment
  • Prepared research solutions should use validated storage conditions appropriate to the compound and study design
  • Protect from unnecessary heat, direct light and repeated temperature fluctuations
  • For laboratory preparation, lyophilised TB-500 is typically reconstituted with bacteriostatic water, and the peptide calculator works out the resulting concentration for your vial size
Full storage guide
Related

Related Compounds

Researchers working with TB-500 may also be interested in [BPC-157], [BPC-157 + TB-500], [KLOW], [GHK-Cu] and [KPV] — other tissue-repair and cell-migration research peptides studied in related research areas.

Compliance

Research Use Only

  • Laboratory research only
  • Not for human or clinical use
  • Not for human or veterinary consumption
  • Qualified personnel only
Questions

TB-500 Frequently Asked Questions

What is TB-500?

TB-500 is a research-product name associated with Thymosin Beta-4-related peptide material, supplied by Crown Peptides in 5mg and 10mg vials.

What is Thymosin beta-4?

Thymosin beta-4 is a naturally occurring 43-amino-acid peptide that binds monomeric actin.

What is TB-500 / Thymosin beta-4 researched for?

Research includes actin dynamics, cell migration, angiogenesis, wound-healing models and tissue-response biology.

Why is actin important in this research?

Actin is a core cytoskeletal protein involved in cell shape, movement and structural organisation.

How should the exact identity of TB-500 be confirmed?

Use the batch-specific Certificate of Analysis and product specification, because commercial TB-500 naming does not always establish that the material is identical to full-length endogenous thymosin beta-4.

Is TB-500 the same as thymosin beta-4?

TB-500 is the name used in research supply for thymosin beta-4 material. The Crown Peptides TB-500 specification matches the full 43-amino-acid sequence (C212H350N56O78S, 4963.49 g/mol), and each batch's identity is confirmed by mass spectrometry on its certificate of analysis.

What is the difference between TB-500 and BPC-157?

They are different peptides with different mechanisms. TB-500 is a 43-amino-acid peptide whose research centres on actin binding, cell migration and angiogenesis. BPC-157 is a 15-amino-acid peptide derived from a gastric protein, studied mainly for growth-factor and nitric-oxide signalling. Our BPC-157 vs TB-500 guide covers the comparison in full.

Why are TB-500 and BPC-157 researched together?

Because they act through different pathways, researchers often study them side by side in tissue-repair models to look at complementary effects. Crown Peptides also supplies the two pre-combined as the Wolverine Stack.

What is the LKKTETQ sequence?

LKKTETQ is residues 17 to 23 of thymosin beta-4 and forms its actin-binding site. Research has linked this region to the peptide's effects on cell migration and angiogenesis.

Should I choose the 5mg or 10mg vial?

Both contain the same peptide. The choice usually comes down to how much material a study needs and the concentration you want after reconstitution, and the peptide calculator shows how vial size and diluent volume affect that. Packs of 5 and 10 vials are also available, saving 15% and 25% on every vial.

Can I buy TB-500 in the UK from Crown Peptides?

Yes. TB-500 is available in 5mg and 10mg vials, as single vials or in packs of 5 and 10. Orders placed before 2pm on a working day are dispatched the same day from the UK, with free tracked UK delivery on orders over £100.

How can I check the purity of my TB-500 batch?

Every batch is HPLC tested for purity and mass spectrometry verified for identity, and the certificate of analysis is published in full on our Lab Reports page, so you can check it before you order.

Read the batch certificate before you order

Every batch is published openly — identity, purity and batch number, with no account needed.

View lab reports

Supplied for laboratory research purposes only — not for human consumption or for medical, veterinary or diagnostic use.

All Batches Purity Tested

Each batch undergoes internal analytical verification using chromatographic and spectrometric methods prior to lyophilisation.

• HPLC Analysis
• Mass Spectrometry Confirmation
• Batch Traceability

For Research Use Only

By purchasing this product you confirm that you are a qualified researcher and that this compound will be used exclusively for laboratory research purposes.

Not for Human Consumption

This product is not intended for diagnostic or therapeutic use.

Any human or medical use is strictly prohibited.

Store Safely at All Times

Store in a cool, dry, secure and sterile environment away from any unauthorised persons or children.

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Disclaimer: All products are sold strictly for laboratory research purposes only. Not for human or veterinary use, consumption, therapeutic, or diagnostic application. By purchasing, you confirm you are a qualified professional and legally permitted to handle these materials in compliance with all applicable laws and regulations. Misuse, resale for unauthorised purposes, or unlawful application is strictly prohibited. Crown Peptides UK disclaims all liability for improper use, handling, or regulatory non-compliance.

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